We hypothesize that epigenetic dysregulation in the brainstem has a critical role in the pathogenesis of AD. The main aim of the project is therefore to establish the exact role of DNA (hydroxyl)methylation within the brainstem 5-HT and NA neurotransmitter systems in the development and course of AD, which will be addressed by the following specific objectives (see also Figure 1):
By integrating classical and pioneering hypotheses on the aetiology of AD, this translational, multi-level approach will identify novel (epigenetic-based) loci and pathways to be used in order to better diagnose, prevent, attenuate or possibly reverse AD’s pathophysiology.
Figure 1: Schematic overview of translational study design.